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WTCCC3 - Wellcome Trust Case-Control Consortium 3

Defining the genetic basis of interactions between donor and recipient DNA that determine early and late renal transplant dysfunction

Patients with kidney transplants are at significant risk of transplant failure which means returning to dialysis (kidney replacement therapy) or having another kidney transplant. We do not know which genes are responsible for this kidney transplant failure and this study will help to determine this. It remains unclear which of the large number of patients with kidney transplants will get worsening kidney function and therefore the complete failure of their transplant. Variation in the sequence of DNA between transplant recipients and their donor is likely to be the major explanation for the differences in the chances of progression to kidney transplant failure. This study aims to find out which genes contribute to progressive transplant failure and early kidney transplant damage. Success would lead to the development of prevention strategies for kidney transplant failure as well as improved methods of monitoring for those patients who have kidney transplants. Finding out which genetic markers are associated with worse transplant survival will also allow us to match donor kidneys to potential recipients in such a way as to maximise the lifespan of both the transplant and the patient.